Biocrystallography

Official course code: 02-BCRA (5 ECTS points)
Lecture course: 15 h
Lecturer: Prof. Mariusz Jaskolski
Laboratory practicals: 30 h
Tutor for practical exercises: Dr. Szymon Krzywda
Semester: summer
Lectures: Monday and Wednesday 8:00-9:30
Place: Room 134 (Suszko seminar room), Coll. Chemicum
Beginning: February 20, 2012
Practicals: Monday 12:00-16:00, Venue: by appointment
Beginning: March 12, 2012
Student consultations: Monday 11:00-12:00, Room 374 (Prof. Mariusz Jaskolski) and Thursday 11:15-12:15, Room 376 (Dr. Szymon Krzywda)

Material covered

Principles of protein structure
Classification of protein folds
Protein handling and crystallization
Modern diffraction techniques
Phasing methods in protein crystallography
Electron density maps and model building
Protein Data Bank (PDB) and validation of protein models

Practicals

Literature

G. Rhodes, Crystallography Made Crystal Clear, Academic Press, New York 2006.
C. Branden, J. Tooze, Introduction to Protein Structure, Garland Publishing, New York 1998 (2nd edition).
A. Wlodawer, W. Minor, Z. Dauter, M. Jaskolski, Crystallography for non-crystallographers. FEBS J. 275, 1-20 (2007).
A PDF file is available here
M. Jaskolski, From atomic resolution to molecular giants: an overview of crystallographic studies of biological macromolecules with synchrotron radiation. Acta Phys. Polon. A 117, 257-263 (2010).
A PDF file is available here

Assessment

Written multiple-choice test examination
First term: May 7, 2012 (Monday), 9:00-10:00, Room 60
Second term (only if failed first test): May 14, 2012 (Monday), 9:00-10:00, Room 60

Last modification: January 28, 2012 (MJ)